Integrative Modeling for Genome wide Regulation of Gene Expression

Integrative Modeling for Genome wide Regulation of Gene Expression


  • Author :
  • Publisher : Stanford University
  • Release Date : 2010
  • Genre:
  • Pages :
  • ISBN 10 : STANFORD:yy671zp7735


Integrative Modeling for Genome wide Regulation of Gene Expression Book Description :

High-throughput genomics has been increasingly generating the massive amount of genome-wide data. With proper modeling methodologies, we can expect to archive a more comprehensive understanding of the regulatory mechanisms of biological systems. This work presents integrative approaches for the modeling and analysis of gene regulatory systems. In mammals, gene expression regulation is combinatorial in nature, with diverse roles of regulators on target genes. Microarrays (such as Exon Arrays) and RNA-Seq can be used to quantify the whole spectrum of RNA transcripts. ChIP-Seq is being used for the identification of transcription factor (TF) binding sites and histone modification marks. RNA interference (RNAi), coupled with gene expression profiles, all...

Big Mechanisms in Systems Biology

Big Mechanisms in Systems Biology


  • Author : Bor-Sen Chen
  • Publisher : Academic Press
  • Release Date : 2016-10-25
  • Genre: Medical
  • Pages :
  • ISBN 10 : 9780128097076


Big Mechanisms in Systems Biology Book Description :

Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may...

Salmonella host pathogen interactions

Salmonella host pathogen interactions


  • Author : John S. Gunn
  • Publisher : Frontiers Media SA
  • Release Date : 2011-11-01
  • Genre:
  • Pages :
  • ISBN 10 : 9782889190058


Salmonella host pathogen interactions Book Description :

This Research Topic provides updated information on several important areas of Salmonella host cell interaction. Articles begin on topics outside of the host cell, examining the transit to and interaction with the epithelium, including pattern recognition. Once inside the host cell, topics of manuscripts include examination of the Salmonella-containing vacuole, its ability to resist intracellular killing, and the bacterial gene induction within the host cells responsible for survival. Finally, knowledge concerning carriage in and transmission from the infected host are discussed.This Research Topic provides updated information on several important areas of Salmonella host cell interaction. Articles begin on topics outside of the host cell, examining ...

Practical Applications of Computational Biology and Bioinformatics  13th International Conference

Practical Applications of Computational Biology and Bioinformatics 13th International Conference


  • Author : Florentino Fdez-Riverola
  • Publisher : Springer
  • Release Date : 2019-08-20
  • Genre: Computers
  • Pages :
  • ISBN 10 : 9783030238735


Practical Applications of Computational Biology and Bioinformatics 13th International Conference Book Description :

This book features 21 papers spanning many different sub-fields in bioinformatics and computational biology, presenting the latest research on the practical applications to promote fruitful interactions between young researchers in different areas related to the field. Next-generation sequencing technologies, together with other emerging and diverse experimental techniques, are evolving rapidly, creating numerous types of omics data. These, in turn, are creating new challenges for the expanding fields of bioinformatics and computational biology, which seek to analyse, process, integrate and extract meaningful knowledge from such data. This calls for new algorithms and approaches from fields such as databases, statistics, data mining, machine learning...

Index Medicus

Index Medicus


  • Author :
  • Publisher :
  • Release Date : 2004
  • Genre: Medicine
  • Pages :
  • ISBN 10 : OSU:32436011091889


Index Medicus Book Description :

...

Bayesian Inference for Gene Expression and Proteomics
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Bayesian Inference for Gene Expression and Proteomics


  • Author : Kim-Anh Do
  • Publisher : Cambridge University Press
  • Release Date : 2006-07-24
  • Genre: Mathematics
  • Pages :
  • ISBN 10 : 9780521860925


Bayesian Inference for Gene Expression and Proteomics Book Description :

Expert overviews of Bayesian methodology, tools and software for multi-platform high-throughput experimentation....

Statistics and Informatics in Molecular Cancer Research

Statistics and Informatics in Molecular Cancer Research


  • Author : Carsten Wiuf
  • Publisher : OUP Oxford
  • Release Date : 2009-06-18
  • Genre: Medical
  • Pages :
  • ISBN 10 : 9780191579950


Statistics and Informatics in Molecular Cancer Research Book Description :

Molecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences. Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the ...

Systems Biology of Microbial Infection

Systems Biology of Microbial Infection


  • Author : Reinhard Guthke
  • Publisher : Frontiers E-books
  • Release Date :
  • Genre:
  • Pages :
  • ISBN 10 : 9782889190607


Systems Biology of Microbial Infection Book Description :

The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting molecular networks of the host and the pathogen. The aim is to u...

Standards of Mouse Model Phenotyping

Standards of Mouse Model Phenotyping


  • Author : Martin Hrabé de Angelis
  • Publisher : John Wiley & Sons
  • Release Date : 2009-09-03
  • Genre: Science
  • Pages :
  • ISBN 10 : 9783527608706


Standards of Mouse Model Phenotyping Book Description :

This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner....